The effects of sensory deprivation

James H. Thomas ()
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James H. Thomas: University of Washington

Nature, 1999, vol. 402, issue 6763, 740-741

Abstract: The study of lifespan in worms has mainly evolved around the dauer-formation-2 gene (daf-2), which, when mutated, results in a dramatic extension of lifespan. A similar extension has now been observed in worms mutated in a range of genes that also affect the shape and function of sensory neurons. These results imply that sensory neurons can exert a strong effect on lifespan, and this link is thought to involve an insulin-signalling pathway.

Date: 1999
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DOI: 10.1038/45422

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