BMP signalling specifies the pyloric sphincter

Devyn M. Smith and Clifford J. Tabin ()
Additional contact information
Devyn M. Smith: Harvard Medical School
Clifford J. Tabin: Harvard Medical School

Nature, 1999, vol. 402, issue 6763, 748-749

Abstract: Abstract Sphincters are muscular valves that form at the boundaries between organs of the gut; for example, the pyloric sphincter forms at the junction of the small intestine and stomach. We show here that signalling by bone morphogenetic protein (BMP) from the avian small intestine induces the cells of the adjacent gizzard (the equivalent of the stomach in the chicken) primordium to form a sphincter. This finding and related studies of the role of Hox genes in the specification of the iliocaecal sphincter1 provide insights into the processes by which new cell fates are specified at the borders between distinct embryological domains.

Date: 1999
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/45439 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:402:y:1999:i:6763:d:10.1038_45439

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/45439

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().