Circadian clocks limited by noise

Naama Barkai and Stanislas Leibler ()
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Naama Barkai: Princeton University
Stanislas Leibler: Princeton University

Nature, 2000, vol. 403, issue 6767, 267-268

Abstract: Abstract Circadian rhythms, which provide internal daily periodicity, are used by a wide range of organisms to anticipate daily changes in the environment1. It seems that these organisms generate circadian periodicity by similar biochemical networks within a single cell2. A model based on the common features of these biochemical networks shows that a circadian network can oscillate reliably in the presence of stochastic biochemical noise and when cellular conditions are altered. We propose that the ability to resist such perturbations imposes strict constraints on the oscillation mechanisms underlying circadian periodicity in vivo.

Date: 2000
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DOI: 10.1038/35002258

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