Nodal signalling in vertebrate development

Alexander F. Schier () and Michael M. Shen ()
Additional contact information
Alexander F. Schier: Developmental Genetics Program Skirball Institute of Biomolecular Medicine, New York University School of Medicine
Michael M. Shen: UMDNJ-Robert Wood Johnson Medical School

Nature, 2000, vol. 403, issue 6768, 385-389

Abstract: Abstract Communication between cells during early embryogenesis establishes the basic organization of the vertebrate body plan. Recent work suggests that a signalling pathway centering on Nodal, a transforming growth factor β-related signal, is responsible for many of the events that configure the vertebrate embryo. The activity of Nodal signals is regulated extracellularly by EGF-CFC cofactors and antagonists of the Lefty and Cerberus families of proteins, allowing precise control of mesoderm and endoderm formation, the positioning of the anterior–posterior axis, neural patterning and left–right axis specification.

Date: 2000
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/35000126 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:403:y:2000:i:6768:d:10.1038_35000126

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/35000126

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().