Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1

Maio S. Chen, Andrea B. Huber, Marjan E. van der Haar, Marcus Frank, Lisa Schnell, Adrian A. Spillmann, Franziska Christ and Martin E. Schwab
Additional contact information
Maio S. Chen: Brain Research Institute, University of Zurich and Swiss Federal Institute of Technology Zurich
Andrea B. Huber: Brain Research Institute, University of Zurich and Swiss Federal Institute of Technology Zurich
Marjan E. van der Haar: Brain Research Institute, University of Zurich and Swiss Federal Institute of Technology Zurich
Marcus Frank: Brain Research Institute, University of Zurich and Swiss Federal Institute of Technology Zurich
Lisa Schnell: Brain Research Institute, University of Zurich and Swiss Federal Institute of Technology Zurich
Adrian A. Spillmann: Brain Research Institute, University of Zurich and Swiss Federal Institute of Technology Zurich
Franziska Christ: Brain Research Institute, University of Zurich and Swiss Federal Institute of Technology Zurich
Martin E. Schwab: Brain Research Institute, University of Zurich and Swiss Federal Institute of Technology Zurich

Nature, 2000, vol. 403, issue 6768, 434-439

Abstract: Abstract The capacity of the adult brain and spinal cord to repair lesions by axonal regeneration or compensatory fibre growth is extremely limited. A monoclonal antibody (IN-1) raised against NI-220/250, a myelin protein that is a potent inhibitor of neurite growth, promoted axonal regeneration and compensatory plasticity following lesions of the central nervous system (CNS) in adult rats1,2,3,4. Here we report the cloning of nogo A, the rat complementary DNA encoding NI-220/250. The nogo gene encodes at least three major protein products (Nogo-A, -B and -C). Recombinant Nogo-A is recognized by monoclonal antibody IN-1, and it inhibits neurite outgrowth from dorsal root ganglia and spreading of 3T3 fibroblasts in an IN-1-sensitive manner. Antibodies against Nogo-A stain CNS myelin and oligodendrocytes and allow dorsal root ganglion neurites to grow on CNS myelin and into optic nerve explants. These data show that Nogo-A is a potent inhibitor of neurite growth and an IN-1 antigen produced by oligodendrocytes, and may allow the generation of new reagents to enhance CNS regeneration and plasticity.

Date: 2000
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/35000219 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:403:y:2000:i:6768:d:10.1038_35000219

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/35000219

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().