Inhibitor of neurite outgrowth in humans

Rabinder Prinjha, Stephen E. Moore, Mary Vinson, Sian Blake, Rachel Morrow, Gary Christie, David Michalovich, David L. Simmons and Frank S. Walsh ()
Additional contact information
Rabinder Prinjha: Department of Neuroscience Research
Stephen E. Moore: Department of Neuroscience Research
Mary Vinson: Department of Neuroscience Research
Sian Blake: Department of Neuroscience Research
Rachel Morrow: Department of Neuroscience Research
Gary Christie: Department of Neuroscience Research
David Michalovich: Departments of Neuroscience Research and Bioinformatics
David L. Simmons: Department of Neuroscience Research
Frank S. Walsh: Department of Neuroscience Research

Nature, 2000, vol. 403, issue 6768, 383-384

Abstract: Abstract Axons are generally believed to be incapable of regeneration in the adult central nervous system1,2. Inhibition results from physical barriers imposed by glial scars, a lack of neurotrophic factors, and growth-inhibitory molecules associated with myelin3,4,5, the insulating axon sheath. These molecules include proteoglycans6, myelin-associated glycoprotein3,5 and, in bovine brain, two proteins called Nogo7,8,9. We have used this bovine sequence to identify the human Nogo gene and have isolated complementary DNA clones encoding three different Nogo isoforms that are potent inhibitors of neurite outgrowth and which may help block the regeneration of the central nervous system in adults.

Date: 2000
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/35000287 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:403:y:2000:i:6768:d:10.1038_35000287

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/35000287

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().