Modulation of A-type potassium channels by a family of calcium sensors

W. Frank An, Mark R. Bowlby, Maria Betty, Jie Cao, Huai-Ping Ling, Grace Mendoza, Joseph W. Hinson, Karen I. Mattsson, Brian W. Strassle, James S. Trimmer and Kenneth J. Rhodes ()
Additional contact information
W. Frank An: Millennium Pharmaceuticals
Mark R. Bowlby: Wyeth-Ayerst Research
Maria Betty: Wyeth-Ayerst Research
Jie Cao: Millennium Pharmaceuticals
Huai-Ping Ling: Wyeth-Ayerst Research
Grace Mendoza: Wyeth-Ayerst Research
Joseph W. Hinson: Wyeth-Ayerst Research
Karen I. Mattsson: Wyeth-Ayerst Research
Brian W. Strassle: Wyeth-Ayerst Research
James S. Trimmer: Department of Biochemistry and Cell Biology
Kenneth J. Rhodes: Wyeth-Ayerst Research

Nature, 2000, vol. 403, issue 6769, 553-556

Abstract: Abstract In the brain and heart, rapidly inactivating (A-type) voltage-gated potassium (Kv) currents operate at subthreshold membrane potentials to control the excitability of neurons and cardiac myocytes1,2. Although pore-forming α-subunits of the Kv4, or Shal-related, channel family form A-type currents in heterologous cells3, these differ significantly from native A-type currents. Here we describe three Kv channel-interacting proteins (KChIPs) that bind to the cytoplasmic amino termini of Kv4 α-subunits. We find that expression of KChIP and Kv4 together reconstitutes several features of native A-type currents by modulating the density, inactivation kinetics and rate of recovery from inactivation of Kv4 channels in heterologous cells. All three KChIPs co-localize and co-immunoprecipitate with brain Kv4 α-subunits, and are thus integral components of native Kv4 channel complexes. The KChIPs have four EF-hand-like domains and bind calcium ions. As the activity and density of neuronal A-type currents tightly control responses to excitatory synaptic inputs, these KChIPs may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium.

Date: 2000
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/35000592 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:403:y:2000:i:6769:d:10.1038_35000592

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/35000592

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().