Demethylation of the zygotic paternal genome

Wolfgang Mayer, Alain Niveleau, Jörn Walter, Reinald Fundele and Thomas Haaf ()
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Wolfgang Mayer: Max Planck Institute of Molecular Genetics
Alain Niveleau: Molecular and Structural Virology Unit, Université J. Fourier de Grenoble
Jörn Walter: Max Planck Institute of Molecular Genetics
Reinald Fundele: Max Planck Institute of Molecular Genetics
Thomas Haaf: Max Planck Institute of Molecular Genetics

Nature, 2000, vol. 403, issue 6769, 501-502

Abstract: Abstract In mammals, both parental genomes undergo dramatic epigenetic changes after fertilization to form the diploid somatic genome. Here we show that the paternal genome in the mouse is significantly and actively demethylated within 6–8 hours of fertilization, before the onset of DNA replication, whereas the maternal genome is demethylated after several cleavage divisions. This active demethylation of the paternal genome may be associated with epigenetic remodelling of sperm chroma-tin, in order to establish parent-specific developmental programmes during early embryogenesis.

Date: 2000
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DOI: 10.1038/35000656

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