The organizer factors Chordin and Noggin are required for mouse forebrain development

Daniel Bachiller, John Klingensmith, C. Kemp, J. A. Belo, R. M. Anderson, S. R. May, J. A. McMahon, A. P. McMahon, R. M. Harland, J. Rossant and E. M. De Robertis
Additional contact information
Daniel Bachiller: University of California
John Klingensmith: Duke University Medical Center
C. Kemp: University of California
J. A. Belo: University of California
R. M. Anderson: Duke University Medical Center
S. R. May: Duke University Medical Center
J. A. McMahon: Harvard University
A. P. McMahon: Harvard University
R. M. Harland: University of California
J. Rossant: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto
E. M. De Robertis: University of California

Nature, 2000, vol. 403, issue 6770, 658-661

Abstract: Abstract In mice, there is evidence suggesting that the development of head and trunk structures is organized by distinctly separated cell populations1,2. The head organizer is located in the anterior visceral endoderm (AVE) and the trunk organizer in the node and anterior primitive streak. In amphibians, Spemann's organizer, which is homologous to the node, partially overlaps with anterior endoderm cells expressing homologues of the AVE markers cerberus, Hex and Hesx1 (refs 3,4,5,6). For mice, this raises the question of whether the AVE and node are independent of each other, as suggested by their anatomical separation, or functionally interdependent as is the case in amphibians3,4,5. Chordin and Noggin are secreted bone morphogenetic protein (BMP) antagonists7,8 expressed in the mouse node, but not in the AVE. Here we show that mice double-homozygous mutants that are for chordin and noggin display severe defects in the development of the prosencephalon. The results show that BMP antagonists in the node and its derivatives are required for head development.

Date: 2000
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DOI: 10.1038/35001072

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