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Design by necessity

Gregory A. Petsko ()
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Gregory A. Petsko: Rosenstiel Basic Medical Sciences Research Center, Brandeis University

Nature, 2000, vol. 403, issue 6770, 606-607

Abstract: Creating new enzymes by ‘rational design’ has proved to be extremely difficult. A new approach combines structural modification with natural selection — so-called ‘directed evolution’. With this technique, one enzyme in a biosynthetic pathway can be converted into another enzyme with a completely different function.

Date: 2000
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DOI: 10.1038/35001176

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