Raising the roof

Miguel Manzanares () and Robb Krumlauf ()
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Miguel Manzanares: Instituto Cajal, CSIC
Robb Krumlauf: National Institute for Medical Research, Medical Research Council

Nature, 2000, vol. 403, issue 6771, 720-721

Abstract: Cells in the developing nervous system rely on signals from specific organizing centres to tell them what they should become. The signals they receive depend on their position in the developing neural tube. Cells in the dorsal part of the neural tube receive signals from the roof plate, and this process involves a gene calledLmx1a. Mouse embryos without this gene or with no roof plate lack specific sets of dorsal interneurons.

Date: 2000
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DOI: 10.1038/35001711

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