Leptin and diabetes in lipoatrophic mice

Oksana Gavrilova, Bernice Marcus-Samuels, Lisa R. Leon, Charles Vinson and Marc L. Reitman ()
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Oksana Gavrilova: Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Bernice Marcus-Samuels: Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Lisa R. Leon: Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Charles Vinson: Laboratory of Metabolism, National Cancer Institute, National Institutes of Health
Marc L. Reitman: Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health

Nature, 2000, vol. 403, issue 6772, 850-850

Abstract: Abstract Lipoatrophic (lipodystrophic) diabetes is a disorder in which insulin resistance and hyperglycaemia are associated with a reduced body-fat mass1, in contrast to the usual association of diabetes with obesity. Transgenic mice with differing degrees of fat loss can be used as models for lipoatrophy2,3,4. Using the aP2-SREBP-1c mouse3, which has a moderate fat deficiency, Shimomura et al. showed that leptin treatment reverses the diabetes, concluding that insulin resistance in congenital generalized lipodystrophy can be explained by a leptin deficiency5. However, we have used a more severe model of lipoatrophy, the A-ZIP/F-1 mouse2,6, in which we find that leptin treatment is only slightly effective in correcting diabetes.

Date: 2000
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DOI: 10.1038/35002663

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