The importance of repairing stalled replication forks

Michael M. Cox, Myron F. Goodman, Kenneth N. Kreuzer, David J. Sherratt, Steven J. Sandler and Kenneth J. Marians
Additional contact information
Michael M. Cox: University of Wisconsin-Madison
Myron F. Goodman: University of Southern California
Kenneth N. Kreuzer: Duke University Medical Center
David J. Sherratt: University of Oxford
Steven J. Sandler: University of Massachusetts
Kenneth J. Marians: Molecular Biology Program, Memorial Sloan-Kettering Cancer Center

Nature, 2000, vol. 404, issue 6773, 37-41

Abstract: Abstract The bacterial SOS response to unusual levels of DNA damage has been recognized and studied for several decades. Pathways for re-establishing inactivated replication forks under normal growth conditions have received far less attention. In bacteria growing aerobically in the absence of SOS-inducing conditions, many replication forks encounter DNA damage, leading to inactivation. The pathways for fork reactivation involve the homologous recombination systems, are nonmutagenic, and integrate almost every aspect of DNA metabolism. On a frequency-of-use basis, these pathways represent the main function of bacterial DNA recombination systems, as well as the main function of a number of other enzymatic systems that are associated with replication and site-specific recombination.

Date: 2000
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/35003501 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:404:y:2000:i:6773:d:10.1038_35003501

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/35003501

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().