Light acts directly on organs and cells in culture to set the vertebrate circadian clock

David Whitmore, Nicholas S. Foulkes and Paolo Sassone-Corsi ()
Additional contact information
David Whitmore: Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS-INSERM-ULP
Nicholas S. Foulkes: Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS-INSERM-ULP
Paolo Sassone-Corsi: Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS-INSERM-ULP

Nature, 2000, vol. 404, issue 6773, 87-91

Abstract: Abstract The expression of clock genes in vertebrates is widespread and not restricted to classical clock structures1,2. The expression of the Clock gene in zebrafish shows a strong circadian oscillation in many tissues in vivo and in culture, showing that endogenous oscillators exist in peripheral organs3. A defining feature of circadian clocks is that they can be set or entrained to local time, usually by the environmental light–dark cycle4,5. An important question is whether peripheral oscillators are entrained to local time by signals from central pacemakers such as the eyes or are themselves directly light-responsive. Here we show that the peripheral organ clocks of zebrafish are set by light–dark cycles in culture. We also show that a zebrafish-derived cell line contains a circadian oscillator, which is also directly light entrained.

Date: 2000
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/35003589 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:404:y:2000:i:6773:d:10.1038_35003589

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/35003589

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().