Moving in mysterious ways

Alison M. Condliffe and Phillip T. Hawkins ()
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Alison M. Condliffe: Addenbrookes and Papworth Hospitals
Phillip T. Hawkins: Addenbrookes and Papworth Hospitals

Nature, 2000, vol. 404, issue 6774, 135-137

Abstract: Certain white blood cells home in on pathogens attacking the body by following gradients of chemoattractant to their targets. Cell movement in this chemotactic process requires extension of the cell's leading edge. That, it now emerges, stems from generation of lipid signals by an enzyme called phosphoinositide-3-OH kinase. The result is a highly polarized signalling cascade which leads to directed movement.

Date: 2000
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DOI: 10.1038/35004693

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