Gene silencing in worms and fungi

Caterina Catalanotto, Gianluca Azzalin, Giuseppe Macino and Carlo Cogoni ()
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Caterina Catalanotto: Universita' di Roma La Sapienza
Gianluca Azzalin: Universita' di Roma La Sapienza
Giuseppe Macino: Universita' di Roma La Sapienza
Carlo Cogoni: Universita' di Roma La Sapienza

Nature, 2000, vol. 404, issue 6775, 245-245

Abstract: Abstract The introduction into cells of foreign nucleic acid molecules can induce sequence-specific gene silencing in some organisms. Here we show that two distantly related organisms, the nematode Caenorhabditis elegans and the fungus Neurospora crassa, which have quite different mechanisms of gene silencing, both use a similar protein to control the process. This suggests that they may share an ancestral mechanism that evolved to protect the genome against invasion by foreign DNA.

Date: 2000
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DOI: 10.1038/35005169

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