A Drosophila model of Parkinson's disease

Mel B. Feany () and Welcome W. Bender
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Mel B. Feany: Brigham and Women's Hospital and Harvard Medical School and
Welcome W. Bender: Harvard Medical School

Nature, 2000, vol. 404, issue 6776, 394-398

Abstract: Abstract Parkinson's disease is a common neurodegenerative syndrome characterized by loss of dopaminergic neurons in the substantia nigra, formation of filamentous intraneuronal inclusions (Lewy bodies) and an extrapyramidal movement disorder. Mutations in the α-synuclein gene are linked to familial Parkinson's disease1,2 and α-synuclein accumulates in Lewy bodies and Lewy neurites3,4,5. Here we express normal and mutant forms of α-synuclein in Drosophila and produce adult-onset loss of dopaminergic neurons, filamentous intraneuronal inclusions containing α-synuclein and locomotor dysfunction. Our Drosophila model thus recapitulates the essential features of the human disorder, and makes possible a powerful genetic approach to Parkinson's disease.

Date: 2000
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DOI: 10.1038/35006074

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