Non-haemolytic β-amino-acid oligomers

Emilie A. Porter, Xifang Wang, Hee-Seung Lee, Bernard Weisblum and Samuel H. Gellman ()
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Emilie A. Porter: University of Wisconsin
Xifang Wang: University of Wisconsin
Hee-Seung Lee: University of Wisconsin
Bernard Weisblum: University of Wisconsin
Samuel H. Gellman: University of Wisconsin

Nature, 2000, vol. 404, issue 6778, 565-565

Abstract: Abstract Pathogenic bacteria are becoming increasingly resistant to common antibiotics, stimulating an intensive search for new ones. Knowing that a class of medium-sized peptides (magainins1) are widely used by host organisms as a defence against microbial invasion2, we developed a β-amino-acid oligomer (β-peptide) that mimics these natural antibiotics and tested it for antimicrobial activity. We find not only that the activity of our β-peptide is comparable to that of a magainin derivative but also that it is effective against four bacterial species, including two pathogens that are resistant to common antibiotics.

Date: 2000
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DOI: 10.1038/35007145

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