Specificities of heparan sulphate proteoglycans in developmental processes

Norbert Perrimon and Merton Bernfield
Additional contact information
Norbert Perrimon: Howard Hughes Medical Institute, Harvard Medical School
Merton Bernfield: Harvard Medical School, Children's Hospital

Nature, 2000, vol. 404, issue 6779, 725-728

Abstract: Abstract Heparan sulphate proteoglycans are abundant cell-surface molecules that consist of a protein core to which heparan sulphate glycosaminoglycan chains are attached. The functions of these molecules have remained mostly underappreciated by developmental biologists; however, the actions of important signalling molecules, for example Wnt and Hedgehog, depend on them. To understand both the mechanisms by which ligands involved in development interact with their receptors and how morphogens pattern tissues, biologists need to consider the functions of heparan sulphate proteoglycans in signalling and developmental patterning.

Date: 2000
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/35008000 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:404:y:2000:i:6779:d:10.1038_35008000

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/35008000

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().