New guardians of the genome

David B. Roth () and Martin Gellert ()
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David B. Roth: Baylor College of Medicine
Martin Gellert: the Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health

Nature, 2000, vol. 404, issue 6780, 823-824

Abstract: DNA breaks arise frequently in cells, and need to be repaired. Systems that repair such breaks often have a role in preventing cancer-causing mutations or chromosome rearrangements, and so are called 'caretakers'. The 'non-homologous-end-joining' proteins can now be added to this list of caretakers.

Date: 2000
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DOI: 10.1038/35009180

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