Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation

Carl-Philipp Heisenberg (), Masazumi Tada, Gerd-Jörg Rauch, Leonor Saúde, Miguel L. Concha, Robert Geisler, Derek L. Stemple, James C. Smith and Stephen W. Wilson
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Carl-Philipp Heisenberg: University College London
Masazumi Tada: Division of Developmental Biology National Institute for Medical Research
Gerd-Jörg Rauch: Max-Planck-Institut für Entwicklungsbiologie
Leonor Saúde: Division of Developmental Biology National Institute for Medical Research
Miguel L. Concha: University College London
Robert Geisler: Max-Planck-Institut für Entwicklungsbiologie
Derek L. Stemple: Division of Developmental Biology National Institute for Medical Research
James C. Smith: Division of Developmental Biology National Institute for Medical Research
Stephen W. Wilson: University College London

Nature, 2000, vol. 405, issue 6782, 76-81

Abstract: Abstract Vertebrate gastrulation involves the specification and coordinated movement of large populations of cells that give rise to the ectodermal, mesodermal and endodermal germ layers. Although many of the genes involved in the specification of cell identity during this process have been identified, little is known of the genes that coordinate cell movement. Here we show that the zebrafish silberblick (slb) locus1 encodes Wnt11 and that Slb/Wnt11 activity is required for cells to undergo correct convergent extension movements during gastrulation. In the absence of Slb/Wnt11 function, abnormal extension of axial tissue results in cyclopia and other midline defects in the head2. The requirement for Slb/Wnt11 is cell non-autonomous, and our results indicate that the correct extension of axial tissue is at least partly dependent on medio-lateral cell intercalation in paraxial tissue. We also show that the slb phenotype is rescued by a truncated form of Dishevelled that does not signal through the canonical Wnt pathway3, suggesting that, as in flies4, Wnt signalling might mediate morphogenetic events through a divergent signal transduction cascade. Our results provide genetic and experimental evidence that Wnt activity in lateral tissues has a crucial role in driving the convergent extension movements underlying vertebrate gastrulation.

Date: 2000
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DOI: 10.1038/35011068

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