ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation

Hiroaki Kawasaki, Lou Schiltz, Robert Chiu, Keiichi Itakura, Kazunari Taira, Yoshihiro Nakatani and Kazunari K. Yokoyama ()
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Hiroaki Kawasaki: Tsukuba Life Science Center, The Institute of Physical and Chemical Research (RIKEN)
Lou Schiltz: Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health
Robert Chiu: School of Medicine/School of Dentistry, Surgical Oncology/Oral Biology and Medicine, University of California
Keiichi Itakura: Beckman Research Institute of the City of Hope
Kazunari Taira: National Institute for Advanced Interdisciplinary Research and National Institute of Bioscience and Human Technology, Agency of Industrial Science & Technology, MITI
Yoshihiro Nakatani: Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health
Kazunari K. Yokoyama: Tsukuba Life Science Center, The Institute of Physical and Chemical Research (RIKEN)

Nature, 2000, vol. 405, issue 6783, 195-200

Abstract: Abstract Transcription factors carry functional domains, which are often physically distinct, for sequence-specific DNA binding, transcriptional activation and regulatory functions. The transcription factor ATF-2 is a DNA-binding protein that binds to cyclic AMP-response elements (CREs), forms a homodimer or heterodimer with c-Jun, and stimulates CRE-dependent transcription1,2,3. Here we report that ATF-2 is a histone acetyltransferase (HAT), which specifically acetylates histones H2B and H4 in vitro. Motif A, which is located in the HAT domain, is responsible for the stimulation of CRE-dependent transcription; moreover, in response to ultraviolet irradiation, phosphorylation of ATF-2 is accompanied by enhanced HAT activity of ATF-2 and CRE-dependent transcription. These results indicate that phosphorylation of ATF-2 controls its intrinsic HAT activity and its action on CRE-dependent transcription. ATF-2 may represent a new class of sequence-specific factors, which are able to activate transcription by direct effects on chromatin components.

Date: 2000
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DOI: 10.1038/35012097

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