Formation of endothelial cell networks

Gabriel Helmlinger, Mitsuhiro Endo, Napoleone Ferrara, Lynn Hlatky and Rakesh K. Jain
Additional contact information
Gabriel Helmlinger: Steele Laboratory, Massachusetts General Hospital, Harvard Medical School
Mitsuhiro Endo: Steele Laboratory, Massachusetts General Hospital, Harvard Medical School
Napoleone Ferrara: Genentech
Lynn Hlatky: Dana-Farber Cancer Institute/Brigham and Women's Hospital, Harvard Medical School
Rakesh K. Jain: Steele Laboratory, Massachusetts General Hospital, Harvard Medical School

Nature, 2000, vol. 405, issue 6783, 139-141

Abstract: Abstract The growth factor VEGF (vascular endothelial growth factor) promotes the formation of blood vessels in a process known as angiogenesis by inducing the proliferation and migration of endothelial cells1. We show here that VEGF has another proangiogenic function — it can stimulate the elongation, network formation and branching of non-proliferating endothelial cells in culture that are deprived of oxygen and nutrients. As endothelial cells in tumours are exposed to chronic or intermittent hypoxic conditions2,3, we propose that autocrine endothelial VEGF contributes to the formation of blood vessels in a tumour and promotes its survival.

Date: 2000
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/35012132 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:405:y:2000:i:6783:d:10.1038_35012132

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/35012132

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().