Silence across the border

Wolf Reik () and Adele Murrell
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Wolf Reik: Laboratory of Developmental Genetics and Imprinting, The Babraham Institute
Adele Murrell: Laboratory of Developmental Genetics and Imprinting, The Babraham Institute

Nature, 2000, vol. 405, issue 6785, 408-409

Abstract: Imprinted genes, such as the closely linked genesH19 and Igf2, are expressed from either the maternal or the paternal chromosome, but not both. A newly discovered mechanism for ‘silencing’ the Igf2 gene on the maternal chromosome involves an ‘insulator’ region found upstream of H19.

Date: 2000
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DOI: 10.1038/35013178

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