Engineering stability in gene networks by autoregulation

Attila Becskei () and Luis Serrano
Additional contact information
Attila Becskei: EMBL, Structures & Biocomputing
Luis Serrano: EMBL, Structures & Biocomputing

Nature, 2000, vol. 405, issue 6786, 590-593

Abstract: Abstract The genetic and biochemical networks which underlie such things as homeostasis in metabolism and the developmental programs of living cells, must withstand considerable variations and random perturbations of biochemical parameters1,2,3. These occur as transient changes in, for example, transcription, translation, and RNA and protein degradation. The intensity and duration of these perturbations differ between cells in a population4. The unique state of cells, and thus the diversity in a population, is owing to the different environmental stimuli the individual cells experience and the inherent stochastic nature of biochemical processes (for example, refs 5 and 6). It has been proposed, but not demonstrated, that autoregulatory, negative feedback loops in gene circuits provide stability7, thereby limiting the range over which the concentrations of network components fluctuate. Here we have designed and constructed simple gene circuits consisting of a regulator and transcriptional repressor modules in Escherichia coli and we show the gain of stability produced by negative feedback.

Date: 2000
References: Add references at CitEc
Citations: View citations in EconPapers (29)

Downloads: (external link)
https://www.nature.com/articles/35014651 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:405:y:2000:i:6786:d:10.1038_35014651

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/35014651

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().