Neutralizing noise in gene networks

Timothy S. Gardner () and James J. Collins ()
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Timothy S. Gardner: Cellicon Biotechnologies
James J. Collins: Boston University

Nature, 2000, vol. 405, issue 6786, 520-521

Abstract: Noise is inherent in gene expression, and can lead to sizeable fluctuations in the concentrations of expressed RNA and proteins. But many biological processes, such as circadian rhythms, are predictable and must be robust to internal noise. New simulations and studies of synthetic gene networks indicate that negative feedback may counteract noise.

Date: 2000
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DOI: 10.1038/35014708

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