Presenilin-1 mutations in Alzheimer's disease

C. Russo, G. Schettini, T. C. Saido, C. Hulette, C. Lippa, L. Lannfelt, B. Ghetti, P. Gambetti (), M. Tabaton and J. K. Teller
Additional contact information
C. Russo: Institute of Pathology, Case Western Reserve University
G. Schettini: National Institute for Cancer Research Advanced Biotechnology Center, Section of Pharmacology University of Genova
T. C. Saido: Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute
C. Hulette: Kathleen Price Bryan Brain Bank and Neuropathology Core, Duke University Medical Center
C. Lippa: MCP Hahnemann University
L. Lannfelt: Karolinska Institute, Geriatric Laboratory, Huddinge Hospital
B. Ghetti: Indiana University Medical Center
P. Gambetti: Institute of Pathology, Case Western Reserve University
M. Tabaton: Institute of Neurology
J. K. Teller: Institute of Pathology, Case Western Reserve University

Nature, 2000, vol. 405, issue 6786, 531-532

Abstract: Abstract Mutations in the gene encoding the protein presenilin-1 are the most common cause of familial Alzheimer's disease1 and they often produce a different disease course from sporadic Alzheimer's and another familial form associated with mutations in the gene encoding β-amyloid precursor protein2. Here we show that a peculiar form of β-amyloid that is devoid of the first ten amino acids accumulates in the brains of patients carrying presenilin-1 mutations, and is more abundant than in subjects affected by the other types of Alzheimer's.

Date: 2000
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/35014735 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:405:y:2000:i:6786:d:10.1038_35014735

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/35014735

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().