Closing in on γ-secretase

Bart De Strooper ()
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Bart De Strooper: Center for Human Genetics, Flanders Interuniversitary Institute for Biotechnology

Nature, 2000, vol. 405, issue 6787, 627-628

Abstract: For decades, a short amyloid peptide called Aβ has been thought to underlie the neurodegeneration characteristic of Alzheimer's disease. This peptide is produced from a longer precursor protein by two protein-cleaving enzymes, known as β-secretase and γ-secretase. Presenilin, a suspect of old, is now revealed as the γ-secretase.

Date: 2000
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DOI: 10.1038/35015193

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