GTPase traffic control

Channing J. Der () and William E. Balch ()
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Channing J. Der: Lineberger Comprehensive Cancer Center
William E. Balch: Department of Cell Biology Scripps Research Institute

Nature, 2000, vol. 405, issue 6788, 749-751

Abstract: Cdc42 is a small GTPase that interacts with various downstream targets to regulate many cellular processes. The latest target to be identified is a subunit of a complex involved in vesicle formation. Surprisingly, this subunit may be required for Cdc42 to induce cells to switch to malignant growth.

Date: 2000
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DOI: 10.1038/35015654

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