Searching for genetic determinants in the new millennium

Neil J. Risch
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Neil J. Risch: Stanford University School of Medicine

Nature, 2000, vol. 405, issue 6788, 847-856

Abstract: Abstract Human genetics is now at a critical juncture. The molecular methods used successfully to identify the genes underlying rare mendelian syndromes are failing to find the numerous genes causing more common, familial, non-mendelian diseases. With the human genome sequence nearing completion, new opportunities are being presented for unravelling the complex genetic basis of non-mendelian disorders based on large-scale genome-wide studies. Considerable debate has arisen regarding the best approach to take. In this review I discuss these issues, together with suggestions for optimal post-genome strategies.

Date: 2000
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DOI: 10.1038/35015718

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