Stable germline transformation of the malaria mosquito Anopheles stephensi

Flaminia Catteruccia, Tony Nolan, Thanasis G. Loukeris, Claudia Blass, Charalambos Savakis, Fotis C. Kafatos and Andrea Crisanti
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Flaminia Catteruccia: Imperial College of Science, Technology and Medicine
Tony Nolan: Imperial College of Science, Technology and Medicine
Thanasis G. Loukeris: European Molecular Biology Laboratory
Claudia Blass: European Molecular Biology Laboratory
Charalambos Savakis: Institute of Molecular Biology and Biotechnology, Research Centre of Crete, Foundation for Research and Technology Hellas
Fotis C. Kafatos: European Molecular Biology Laboratory
Andrea Crisanti: Imperial College of Science, Technology and Medicine

Nature, 2000, vol. 405, issue 6789, 959-962

Abstract: Abstract Anopheline mosquito species are obligatory vectors for human malaria, an infectious disease that affects hundreds of millions of people living in tropical and subtropical countries. The lack of a suitable gene transfer technology for these mosquitoes has hampered the molecular genetic analysis of their physiology, including the molecular interactions between the vector and the malaria parasite. Here we show that a transposon, based on the Minos element1 and bearing exogenous DNA, can integrate efficiently and stably into the germ line of the human malaria vector Anopheles stephensi , through a transposase-mediated process.

Date: 2000
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DOI: 10.1038/35016096

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