A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development

Erik Kupperman, Songzhu An, Nick Osborne, Steven Waldron and Didier Y. R. Stainier ()
Additional contact information
Erik Kupperman: Departments of Biochemistry and Biophysics and
Songzhu An: University of California San Francisco
Nick Osborne: Departments of Biochemistry and Biophysics and
Steven Waldron: Departments of Biochemistry and Biophysics and
Didier Y. R. Stainier: Departments of Biochemistry and Biophysics and

Nature, 2000, vol. 406, issue 6792, 192-195

Abstract: Abstract Coordinated cell migration is essential in many fundamental biological processes including embryonic development, organogenesis, wound healing and the immune response. During organogenesis, groups of cells are directed to specific locations within the embryo. Here we show that the zebrafish miles apart (mil) mutation1,2 specifically affects the migration of the heart precursors to the midline. We found that mutant cells transplanted into a wild-type embryo migrate normally and that wild-type cells in a mutant embryo fail to migrate, suggesting that mil may be involved in generating an environment permissive for migration. We isolated mil by positional cloning and show that it encodes a member of the lysosphingolipid G-protein-coupled receptor family. We also show that sphingosine-1-phosphate is a ligand for Mil, and that it activates several downstream signalling events that are not activated by the mutant alleles. These data reveal a new role for lysosphingolipids in regulating cell migration during vertebrate development and provide the first molecular clues into the fusion of the bilateral heart primordia during organogenesis of the heart.

Date: 2000
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/35018092 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:406:y:2000:i:6792:d:10.1038_35018092

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/35018092

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().