A triclosan-resistant bacterial enzyme

Richard J. Heath and Charles O. Rock ()
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Richard J. Heath: St Jude Children's Research Hospital
Charles O. Rock: St Jude Children's Research Hospital

Nature, 2000, vol. 406, issue 6792, 145-146

Abstract: Abstract Triclosan is an antimicrobial agent that is widely used in a variety of consumer products and acts by inhibiting one of the highly conserved enzymes (enoyl-ACP reductase, or FabI) of bacterial fatty-acid biosynthesis. But several key pathogenic bacteria do not possess FabI, and here we describe a unique triclosan-resistant flavoprotein, FabK, that can also catalyse this reaction in Streptococcus pneumoniae. Our finding has implications for the development of FabI-specific inhibitors as antibacterial agents.

Date: 2000
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DOI: 10.1038/35018162

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