Fringe benefits to carbohydrates

Mark E. Fortini ()
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Mark E. Fortini: Stellar-Chance Laboratories 709C

Nature, 2000, vol. 406, issue 6794, 357-358

Abstract: The Notch signalling pathway is involved in establishing spatial boundaries in tissues during development. The ability of Notch to respond to its signalling partners is modified by a protein called Fringe, and we now know why: Fringe acts as a glycosyltransferase, adding carbohydrate chains to Notch.

Date: 2000
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DOI: 10.1038/35019233

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