Toll-like receptors in the induction of the innate immune response

Alan Aderem and Richard J. Ulevitch
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Alan Aderem: University of Washington
Richard J. Ulevitch: The Scripps Research Institute

Nature, 2000, vol. 406, issue 6797, 782-787

Abstract: Abstract The innate immune response is the first line of defence against infectious disease. The principal challenge for the host is to detect the pathogen and mount a rapid defensive response. A group of proteins that comprise the Toll or Toll-like family of receptors perform this role in vertebrate and invertebrate organisms. This reflects a remarkable conservation of function and it is therefore not surprising that studies of the mechanism by which they act has revealed new and important insights into host defence.

Date: 2000
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DOI: 10.1038/35021228

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