CD1-restricted T-cell responses and microbial infection

Se-Ho Park and Albert Bendelac
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Se-Ho Park: Princeton University
Albert Bendelac: Princeton University

Nature, 2000, vol. 406, issue 6797, 788-792

Abstract: Abstract CD1, a conserved family of major histocompatibility (MHC)-like glycoproteins in mammals, specializes in capturing lipid rather than peptide antigen for presentation to T lymphocytes. The principles and mechanisms of this newly discovered immune strategy differ markedly from those governing classical MHC–peptide presentation. They might be exploited for the design of new lipid-based microbial vaccines and adjuvants.

Date: 2000
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DOI: 10.1038/35021233

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