reply: Kainate receptors and synaptic plasticity

Zuner A. Bortolotto, Vernon R. J. Clarke, Caroline M. Delany, Michel Vignes and Graham L. Collingridge ()
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Zuner A. Bortolotto: Medical School, University of Bristol
Vernon R. J. Clarke: Medical School, University of Bristol
Caroline M. Delany: Medical School, University of Bristol
Michel Vignes: Laboratoire ‘Plasticité Cérébrale’, 628 CNRS, Université Montpellier II
Graham L. Collingridge: Medical School, University of Bristol

Nature, 2000, vol. 406, issue 6799, 957-957

Abstract: Abstract Bortolotto et al. reply — Nicoll et al. challenge our finding that kainate receptors are involved in mossy-fibre LTP in the hippocampus1. Their argument is based on a discrepancy of our results with earlier work, as we show (our Fig. 5)1 that two kainate-receptor antagonists, kynurenate and CNQX, can also block mossy-fibre LTP. We do not dispute that it may be possible to induce mossy-fibre LTP in the presence of kainate-receptor antagonists under certain conditions. For this reason, we neither stated nor implied that activation of kainate receptors is always necessary for mossy-fibre LTP1.

Date: 2000
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DOI: 10.1038/35023077

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