Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen

C. K. Stover, X. Q. Pham, A. L. Erwin, S. D. Mizoguchi, P. Warrener, M. J. Hickey, F.S. L. Brinkman, W. O. Hufnagle, D. J. Kowalik, M. Lagrou, R. L. Garber, L. Goltry, E. Tolentino, S. Westbrock-Wadman, Y. Yuan, L. L. Brody, S. N. Coulter, K. R. Folger, A. Kas, K. Larbig, R. Lim, K. Smith, D. Spencer, G. K.-S. Wong, Z. Wu, I. T. Paulsen, J. Reizer, M. H. Saier, R. E. W. Hancock, S. Lory and M. V. Olson
Additional contact information
C. K. Stover: PathoGenesis Corporation
X. Q. Pham: Box 352145, University of Washington
A. L. Erwin: PathoGenesis Corporation
S. D. Mizoguchi: PathoGenesis Corporation
P. Warrener: PathoGenesis Corporation
M. J. Hickey: PathoGenesis Corporation
F.S. L. Brinkman: Department of Microbiology and Immunology University of British Columbia
W. O. Hufnagle: PathoGenesis Corporation
D. J. Kowalik: PathoGenesis Corporation
M. Lagrou: PathoGenesis Corporation
R. L. Garber: PathoGenesis Corporation
L. Goltry: PathoGenesis Corporation
E. Tolentino: PathoGenesis Corporation
S. Westbrock-Wadman: PathoGenesis Corporation
Y. Yuan: PathoGenesis Corporation
L. L. Brody: PathoGenesis Corporation
S. N. Coulter: PathoGenesis Corporation
K. R. Folger: PathoGenesis Corporation
A. Kas: Box 352145, University of Washington
K. Larbig: Klinische Forschergruppe, Medizinische Hochschule Hannover
R. Lim: Box 352145, University of Washington
K. Smith: Box 352145, University of Washington
D. Spencer: Box 352145, University of Washington
G. K.-S. Wong: Box 352145, University of Washington
Z. Wu: Box 352145, University of Washington
I. T. Paulsen: The Institute for Genomic Research, 9712 Medical Center
J. Reizer: University of California at San Diego
M. H. Saier: University of California at San Diego
R. E. W. Hancock: Department of Microbiology and Immunology University of British Columbia
S. Lory: University of Washington School of Medicine
M. V. Olson: Box 352145, University of Washington

Nature, 2000, vol. 406, issue 6799, 959-964

Abstract: Abstract Pseudomonas aeruginosa is a ubiquitous environmental bacterium that is one of the top three causes of opportunistic human infections. A major factor in its prominence as a pathogen is its intrinsic resistance to antibiotics and disinfectants. Here we report the complete sequence of P. aeruginosa strain PAO1. At 6.3 million base pairs, this is the largest bacterial genome sequenced, and the sequence provides insights into the basis of the versatility and intrinsic drug resistance of P. aeruginosa. Consistent with its larger genome size and environmental adaptability, P. aeruginosa contains the highest proportion of regulatory genes observed for a bacterial genome and a large number of genes involved in the catabolism, transport and efflux of organic compounds as well as four potential chemotaxis systems. We propose that the size and complexity of the P. aeruginosa genome reflect an evolutionary adaptation permitting it to thrive in diverse environments and resist the effects of a variety of antimicrobial substances.

Date: 2000
References: Add references at CitEc
Citations: View citations in EconPapers (8)

Downloads: (external link)
https://www.nature.com/articles/35023079 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:406:y:2000:i:6799:d:10.1038_35023079

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/35023079

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().