Investigating T-cell memory

Alberto Mantovani ()
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Alberto Mantovani: Istituto di Ricerche Farmacologiche ‘Mario Negri’

Nature, 2000, vol. 407, issue 6800, 40-40

Abstract: Abstract Memory is a long-recognized, crucial and poorly understood property of adaptive immunity. Jacob and Baltimore1 have designed an elegant genetic approach to marking memory T cells and their precursors irreversibly and have obtained intriguing results1,2. I suggest that the particular enzyme (human placental alkaline phosphatase) chosen for irreversible marking in postnatal life contributes to certain features of this system and perturbs the homeostatic mechanisms of T-cell activation and death.

Date: 2000
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DOI: 10.1038/35024159

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