reply: Investigating T-cell memory

Charles H. Maris, Joshy Jacob and David Baltimore
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Charles H. Maris: Emory University
Joshy Jacob: Emory University
David Baltimore: California Institute of Technology

Nature, 2000, vol. 407, issue 6800, 40-40

Abstract: Abstract Maris et al. reply — Mantovani suggests that expression of human placental alkaline phosphatase in activated T cells might stimulate an immune response against PLAP and that the anti-PLAP antibodies generated could lead to the elimination of CD8+ T cells expressing large amounts of PLAP on their surface. We therefore tested whether doubly transgenic (GranzymeB–Cre × CD2–STOP–PLAP) mice could mount an antibody response against PLAP during the course of a response against LCMV, and whether the serum of these mice contained antibodies against human PLAP.

Date: 2000
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DOI: 10.1038/35024161

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