Compartmental specificity of cellular membrane fusion encoded in SNARE proteins

James A. McNew, Francesco Parlati, Ryouichi Fukuda, Robert J. Johnston, Keren Paz, Fabienne Paumet, Thomas H. Söllner and James E. Rothman ()
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James A. McNew: Rice University
Ryouichi Fukuda: University of Tokyo

Nature, 2000, vol. 407, issue 6801, 153-159

Abstract: Abstract Membrane-enveloped vesicles travel among the compartments of the cytoplasm of eukaryotic cells, delivering their specific cargo to programmed locations by membrane fusion. The pairing of vesicle v-SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) with target membrane t-SNAREs has a central role in intracellular membrane fusion. We have tested all of the potential v-SNAREs encoded in the yeast genome for their capacity to trigger fusion by partnering with t-SNAREs that mark the Golgi, the vacuole and the plasma membrane. Here we find that, to a marked degree, the pattern of membrane flow in the cell is encoded and recapitulated by its isolated SNARE proteins, as predicted by the SNARE hypothesis.

Date: 2000
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DOI: 10.1038/35025000

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