Vascular-specific growth factors and blood vessel formation

George D. Yancopoulos, Samuel Davis, Nicholas W. Gale, John S. Rudge, Stanley J. Wiegand and Jocelyn Holash
Additional contact information
George D. Yancopoulos: Regeneron Pharmaceuticals, Inc
Samuel Davis: Regeneron Pharmaceuticals, Inc
Nicholas W. Gale: Regeneron Pharmaceuticals, Inc
John S. Rudge: Regeneron Pharmaceuticals, Inc
Stanley J. Wiegand: Regeneron Pharmaceuticals, Inc
Jocelyn Holash: Regeneron Pharmaceuticals, Inc

Nature, 2000, vol. 407, issue 6801, 242-248

Abstract: Abstract A recent explosion in newly discovered vascular growth factors has coincided with exploitation of powerful new genetic approaches for studying vascular development. An emerging rule is that all of these factors must be used in perfect harmony to form functional vessels. These new findings also demand re-evaluation of therapeutic efforts aimed at regulating blood vessel growth in ischaemia, cancer and other pathological settings.

Date: 2000
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DOI: 10.1038/35025215

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