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Perspectives for vascular genomics

Edward M. Rubin () and Alan Tall
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Edward M. Rubin: Columbia University, College of Physicians and Surgeons
Alan Tall: Columbia University, College of Physicians and Surgeons

Nature, 2000, vol. 407, issue 6801, 265-269

Abstract: Abstract Diseases of the vascular system result from a complex mixture of genetic and environmental factors. Data sets, technologies and strategies emanating from the human genome programme have been applied to the analysis of both rare single-gene and common multigenic vascular disorders. Genomic approaches including inter- and intraspecies sequence comparisons, genotyping with dense marker sets spanning the genome, large-scale mutagenesis screens of model organisms, and genome-wide expression profiling have all begun to contribute to the identification of new genes and mechanisms that are central to cardiovascular disease processes.

Date: 2000
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DOI: 10.1038/35025236

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