Escape from the immune system

Bruce D. Walker () and Philip J. R. Goulder
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Bruce D. Walker: Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School
Philip J. R. Goulder: Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School

Nature, 2000, vol. 407, issue 6802, 313-314

Abstract: Why is the immune system ultimately unable to control HIV infection? Many of the immune system's cytotoxic T lymphocytes detect an HIV-infected cell by its expression of a peptide from the HIV protein Tat. In so doing, the lymphocytes may encourage the evolution of Tat, allowing HIV to escape immune detection.

Date: 2000
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DOI: 10.1038/35030283

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