Cloning of mice to six generations

Teruhiko Wakayama (), Yoichi Shinkai, Kellie L. K. Tamashiro, Hiroyuki Niida, D. Caroline Blanchard, Robert J. Blanchard, Atsuo Ogura, Kentaro Tanemura, Makoto Tachibana, Anthony C. F. Perry, Diana F. Colgan, Peter Mombaerts and Ryuzo Yanagimachi
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Teruhiko Wakayama: John A. Burns School of Medicine, University of Hawaii
Yoichi Shinkai: Institute for Virus Research, Kyoto University
Kellie L. K. Tamashiro: John A. Burns School of Medicine, University of Hawaii
Hiroyuki Niida: Lawrence Berkeley National Laboratory, University of California
D. Caroline Blanchard: Bekesy Laboratory of Neurobiology, University of Hawaii
Robert J. Blanchard: Bekesy Laboratory of Neurobiology, University of Hawaii
Atsuo Ogura: National Institute of Infectious Disease
Kentaro Tanemura: National Institute of Infectious Disease
Makoto Tachibana: Institute for Virus Research, Kyoto University
Anthony C. F. Perry: The Rockefeller University
Diana F. Colgan: The Rockefeller University
Peter Mombaerts: The Rockefeller University
Ryuzo Yanagimachi: John A. Burns School of Medicine, University of Hawaii

Nature, 2000, vol. 407, issue 6802, 318-319

Abstract: Abstract Mice have been cloned by nuclear transfer into enucleated oocytes1,2,3, and here we describe the reiterative cloning of mice to four and six generations in two independent lines. Successive generations showed no signs of prematureageing, as judged by gross behaviouralparameters, and there was no evidence of shortening of telomeres at the ends of chromosomes, normally an indicator of cellular senescence — in fact, these appeared to increase slightly in length. This increase is surprising, given that the number of mitotic divisions greatly exceeds that of sexually produced animals and that any deleterious effects of cloning might be expected to be amplified in sequentially cloned mice. Our results offer a new approach to the study of organismal ageing.

Date: 2000
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DOI: 10.1038/35030301

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