RNA polymerase II elongation through chromatin

George Orphanides and Danny Reinberg ()
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George Orphanides: Zeneca Central Toxicology Laboratory
Danny Reinberg: Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School

Nature, 2000, vol. 407, issue 6803, 471-476

Abstract: Abstract The machinery that transcribes protein-coding genes in eukaryotic cells must contend with repressive chromatin structures in order to find its target DNA sequences. Diverse arrays of proteins modify the structure of chromatin at gene promoters to help transcriptional regulatory proteins access their DNA recognition sites. The way in which disruption of chromatin structure at a promoter is transmitted through a whole gene has not been defined. Recent breakthroughs suggest that the passage of an RNA polymerase through a gene is coupled to mechanisms that propagate the breakdown of chromatin.

Date: 2000
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DOI: 10.1038/35035000

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