The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum

Andreas Ruepp, Werner Graml, Martha-Leticia Santos-Martinez, Kristin K. Koretke, Craig Volker, H. Werner Mewes, Dmitrij Frishman, Susanne Stocker, Andrei N. Lupas and Wolfgang Baumeister ()
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Andreas Ruepp: Max-Planck-Institut für Biochemie
Werner Graml: Max-Planck-Institut für Biochemie
Martha-Leticia Santos-Martinez: Max-Planck-Institut für Biochemie
Kristin K. Koretke: Bioinformatics, Smith Kline Beecham Pharmaceuticals
Craig Volker: Bioinformatics, Smith Kline Beecham Pharmaceuticals
H. Werner Mewes: GSF-Forschungszentrum für Umwelt und Gesundheit, Munich Information Center for Protein Sequences
Dmitrij Frishman: GSF-Forschungszentrum für Umwelt und Gesundheit, Munich Information Center for Protein Sequences
Susanne Stocker: GSF-Forschungszentrum für Umwelt und Gesundheit, Munich Information Center for Protein Sequences
Andrei N. Lupas: Bioinformatics, Smith Kline Beecham Pharmaceuticals
Wolfgang Baumeister: Max-Planck-Institut für Biochemie

Nature, 2000, vol. 407, issue 6803, 508-513

Abstract: Abstract Thermoplasma acidophilum is a thermoacidophilic archaeon that thrives at 59 °C and pH 2, which was isolated from self-heating coal refuse piles and solfatara fields1,2. Species of the genus Thermoplasma do not possess a rigid cell wall, but are only delimited by a plasma membrane. Many macromolecular assemblies from Thermoplasma , primarily proteases and chaperones, have been pivotal in elucidating the structure and function of their more complex eukaryotic homologues3,4. Our interest in protein folding and degradation led us to seek a more complete representation of the proteins involved in these pathways by determining the genome sequence of the organism. Here we have sequenced the 1,564,905-base-pair genome in just 7,855 sequencing reactions by using a new strategy. The 1,509 open reading frames identify Thermoplasma as a typical euryarchaeon with a substantial complement of bacteria-related genes; however, evidence indicates that there has been much lateral gene transfer between Thermoplasma and Sulfolobus solfataricus, a phylogenetically distant crenarchaeon inhabiting the same environment. At least 252 open reading frames, including a complete protein degradation pathway and various transport proteins, resemble Sulfolobus proteins most closely.

Date: 2000
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DOI: 10.1038/35035069

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