A vertebrate globin expressed in the brain

Thorsten Burmester (), Bettina Weich, Sigrid Reinhardt and Thomas Hankeln
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Thorsten Burmester: Institutes of Zoology,
Bettina Weich: Molecular Genetics, Biosafety Research and Consulting
Sigrid Reinhardt: Johannes Gutenberg University Mainz
Thomas Hankeln: Molecular Genetics, Biosafety Research and Consulting

Nature, 2000, vol. 407, issue 6803, 520-523

Abstract: Abstract Haemoglobins and myoglobins constitute related protein families that function in oxygen transport and storage in humans and other vertebrates1,2. Here we report the identification of a third globin type in man and mouse. This protein is predominantly expressed in the brain, and therefore we have called it neuroglobin. Mouse neuroglobin is a monomer with a high oxygen affinity (half saturation pressure, P50 ≈ 2 torr). Analogous to myoglobin, neuroglobin may increase the availability of oxygen to brain tissue. The human neuroglobin gene (NGB), located on chromosome 14q24, has a unique exon–intron structure. Neuroglobin represents a distinct protein family that diverged early in metazoan evolution, probably before the Protostomia/Deuterostomia split.

Date: 2000
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DOI: 10.1038/35035093

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