Skin abnormalities generated by temporally controlled RXRα mutations in mouse epidermis

Mei Li, Arup Kumar Indra, Xavier Warot, Jacques Brocard, Nadia Messaddeq, Shigeaki Kato, Daniel Metzger and Pierre Chambon ()
Additional contact information
Mei Li: Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, BP 163
Arup Kumar Indra: Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, BP 163
Xavier Warot: Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, BP 163
Jacques Brocard: Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, BP 163
Nadia Messaddeq: Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, BP 163
Shigeaki Kato: Institute of Molecular & Cellular Biosciences, University of Tokyo
Daniel Metzger: Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, BP 163
Pierre Chambon: Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, BP 163

Nature, 2000, vol. 407, issue 6804, 633-636

Abstract: Abstract Nuclear receptors for retinoids (RARs) and vitamin D (VDR), and for some other ligands (TRs, PPARs and LXRs), may be critical in the development and homeostasis of mammalian epidermis1,2,3,4,5,6,7,8. It is believed that these receptors form heterodimers with retinoid X receptors (RXRs) to act as transcriptional regulators9,10. However, most genetic approaches aimed at establishing their physiological functions in the skin have been inconclusive owing either to pleiotropic effects and redundancies between receptor isotypes in gene knockouts, or to equivocal interpretation of dominant-negative mutant studies in transgenic mice1,13,14,15. Moreover, knockout of RXRα, the main skin RXR isotype, is lethal in utero before skin formation11,12,16,17. Here we have resolved these problems by developing an efficient technique to create spatio-temporally controlled somatic mutations in the mouse. We used tamoxifen-inducible Cre–ERT recombinases18,19 to ablate RXRα selectively in adult mouse keratinocytes. We show that RXRα has key roles in hair cycling, probably through RXR/VDR heterodimers, and in epidermal keratinocyte proliferation and differentiation.

Date: 2000
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/35036595 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:407:y:2000:i:6804:d:10.1038_35036595

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/35036595

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().