The biochemistry of apoptosis

Michael O. Hengartner ()
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Michael O. Hengartner: Cold Spring Harbor Laboratory

Nature, 2000, vol. 407, issue 6805, 770-776

Abstract: Abstract Apoptosis — the regulated destruction of a cell — is a complicated process. The decision to die cannot be taken lightly, and the activity of many genes influence a cell's likelihood of activating its self-destruction programme. Once the decision is taken, proper execution of the apoptotic programme requires the coordinated activation and execution of multiple subprogrammes. Here I review the basic components of the death machinery, describe how they interact to regulate apoptosis in a coordinated manner, and discuss the main pathways that are used to activate cell death.

Date: 2000
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DOI: 10.1038/35037710

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